Detalhe da pesquisa
1.
An antibiotic from an uncultured bacterium binds to an immutable target.
Cell
; 186(19): 4059-4073.e27, 2023 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37611581
2.
Teixobactin kills bacteria by a two-pronged attack on the cell envelope.
Nature
; 608(7922): 390-396, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35922513
3.
Regulation of peptidoglycan synthesis by outer-membrane proteins.
Cell
; 143(7): 1097-109, 2010 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21183073
4.
Identification of the potential active site of the septal peptidoglycan polymerase FtsW.
PLoS Genet
; 18(1): e1009993, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34986161
5.
Cooperative Gating of a K+ Channel by Unmodified Biological Anionic Lipids Viewed by Solid-State NMR Spectroscopy.
J Am Chem Soc
; 146(7): 4421-4432, 2024 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38334076
6.
Outer membrane lipoprotein NlpI scaffolds peptidoglycan hydrolases within multi-enzyme complexes in Escherichia coli.
EMBO J
; 39(5): e102246, 2020 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32009249
7.
Two separate mechanisms are involved in membrane permeabilization during lipid oxidation.
Biophys J
; 122(23): 4503-4517, 2023 12 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37905401
8.
Specific Lipid Studies in Complex Membranes by Solid-State NMR Spectroscopy.
Chemistry
; 28(70): e202202472, 2022 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36098094
9.
The bacterial cell division protein fragment EFtsN binds to and activates the major peptidoglycan synthase PBP1b.
J Biol Chem
; 295(52): 18256-18265, 2020 12 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33109614
10.
An Engineered Double Lipid II Binding Motifs-Containing Lantibiotic Displays Potent and Selective Antimicrobial Activity against Enterococcus faecium.
Antimicrob Agents Chemother
; 64(6)2020 05 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32179527
11.
Induced conformational changes activate the peptidoglycan synthase PBP1B.
Mol Microbiol
; 110(3): 335-356, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30044025
12.
Towards the Native Binding Modes of Antibiotics that Target Lipidâ II.
Chembiochem
; 20(14): 1731-1738, 2019 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30725496
13.
Substitutions in PBP2b from ß-Lactam-resistant Streptococcus pneumoniae Have Different Effects on Enzymatic Activity and Drug Reactivity.
J Biol Chem
; 292(7): 2854-2865, 2017 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28062575
14.
Plantaricin NC8 from Lactobacillus plantarum causes cell membrane disruption to Micrococcus luteus without targeting lipid II.
Appl Microbiol Biotechnol
; 102(17): 7465-7473, 2018 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-29982926
15.
New Insight into the Catalytic Mechanism of Bacterial MraY from Enzyme Kinetics and Docking Studies.
J Biol Chem
; 291(29): 15057-68, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27226570
16.
Hit 'em where it hurts: The growing and structurally diverse family of peptides that target lipid-II.
Biochim Biophys Acta
; 1858(5): 947-57, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26523408
17.
Outer-membrane lipoprotein LpoB spans the periplasm to stimulate the peptidoglycan synthase PBP1B.
Proc Natl Acad Sci U S A
; 111(22): 8197-202, 2014 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24821816
18.
New Insights into Nisin's Antibacterial Mechanism Revealed by Binding Studies with Synthetic Lipid II Analogues.
Biochemistry
; 55(1): 232-7, 2016 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26653142
19.
Site-Specific Immobilization of the Peptidoglycan Synthase PBP1B on a Surface Plasmon Resonance Chip Surface.
Chembiochem
; 17(23): 2250-2256, 2016 12 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27709766
20.
Molecular model for the solubilization of membranes into nanodisks by styrene maleic Acid copolymers.
Biophys J
; 108(2): 279-90, 2015 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25606677